CpG-2722 for Combinational Cancer Immunotherapy
用於聯合癌症免疫治療的 CpG-2722
CpG-2722 is a CpG-oligodeoxynucleotide (CpG-ODN) with good immunostimulatory properties for using in combinational cancer therapies.
CpG-2722 是一種 CpG-寡脫氧核苷酸 (CpG-ODN)，具有良好的用於聯合癌症治療的免疫刺激特性。
Targeted indication
Cancer immunotherapy
Status
Pre-clinical studies
Key features
- CpG-2722 has good immunostimulatory in different species including human, mouse, fish, chicken and duck.
- CpG-2722 has good activity in induction of inflammatory cytokines, IL-12 and interferons.
- CpG-2722 can be synthesized automatically with machine, therefore the cost for its production is low.
- CpG-2722 generates cooperative effect when combines with other cancer therapy drugs such as immune checkpoint inhibitor.Thus, can increase the therapeutic effect of immune checkpoint blockade with a low cost.
Market
Although cancer immunotherapy with immune checkpoint blockade is a major achievement in fighting cancer, the efficacy of this treatment is still limited. The response rate of solid tumor patient to this treatment is only 20–30%.
Therefore, there is market for any strategy and agent that can improve the efficacy of therapy with immune checkpoint inhibitor for cancers.
MODE OF ACTION
CpG-2722 tune up tumor microenvironment to facilitate the antitumor action of immune checkpoint blockade.
CpG-2722 activatesTLR9 to induce immune responses including cytokine productions, accumulation of M1 macrophages, and CD8 cytotoxic T-cell in the tumor microenvironment. Immune checkpoint inhibitor, anti-PD-1 releases the brake of the T-cell activation. These effects resulted from the combination of CpG-2722 and anti-PD-1 generating a more effective tumor killing.
EXPERIMENTAL RESULTS
CpG-2722 has potent activity in human peripheral blood mononuclear cell to induce expression of inflammatory cytokines including TNF-¸IL-1, IL-6, IL-12B, IFN- as the B type CpG-ODN, it is also able to activate the expression of type I IFNs, IFN2 and IFN- like a type A CpG-ODN.
In syngeneic orthotopic head and neck cancer animal model, treartment alone with CpG-2722 or anti-PD-1 suppresses tumor growth. Combination of CpG-2722 and anti-PD-1 results in a more effective suppression of the tumor growth than the treatment with these two agents alone.
CpG-ODN has been approved for use as adjuvant in human vaccines. CpG-2722, basically like other CpG-ODNs, is a synthetic phosphothiolated deoxyoligonucleotides. Therefore, it is expected that CpG-2722 is likely to have a good biosafety profile as other CpG-ODNs. However, because the CpG-2722 has different nucleotide sequences and different immunostimulatory activity from other CpG-ODNs, it is still required to follow the relevant government regulations to test the CpG-2722 and approved by the government agency before conducting clinical trials.
CpG-2722 has good water solubility. In this study, it is administrated by intratumor injection.
INTELLECTUAL PROPERTY
SELECTED PUBLICATIONS
Tseng et al. Cancer Immunol Immunother.
2022;71(5):1115-1128.
Chuang et al. Vaccines (Basel).
2020;8(4):639.
Yeh et al. Sci Rep. 2017;7(1):17297.
BUSINESS OPPORTUNITY
License and/or Collaboration
and Sponsored Research
CONTACT
service@biip-dcc.org